It also targets other cells in the pancreas to stop the glucagon signal for generating glucose in the liver.[ref] In clinical trials, GLP-1 RAs improved lipid profiles, increased satiety, slowed gastric emptying, reduced inflammation, and had neuroprotective effects.[ref] The slowing of gastric emptying and reducing inflammation may play a role in weight loss, along with the decrease in appetite and eating less
Specifically, GLP-1R engagement may alleviate endoplasmic reticulum (ER) stress, suppress microglial overactivation, and attenuate the release of pro-inflammatory cytokines and hippocampal neuronal apoptosis
INCREASED ENERGY LEVELS Increase of energy and endurance, allowing individuals to perform better in their daily activities and exercise routines
*Based on manufacturer trials studying the highest doses of oral Wegovy in non-diabetics with obesity, or with overweight plus a weight-related medical condition, when paired with diet and exercise changes (vs ~2% with diet and exercise alone)